Corey J. Wilson
Ph.D., Rice University
The overarching goal of the research conducted in the Wilson Research Group is to establish an integrated experimental and computational framework to translate our understanding of the fundamental principles of biophysics and biochemistry (i.e., the physicochemical properties that confer function) into useful processes, devices, therapies, and diagnostics that will benefit society. To accomplish this the Wilson Research Group focuses on two principle Protein Engineering approaches: (i) computational protein design and (ii) optimized strategies in protein evolution. This research program is an integrated multidisciplinary initiative that includes applied mathematics, computer science, physical chemistry, experimental protein chemistry, biochemistry, cell biology, and molecular biophysics. In turn, our ability to engineer biological materials is a rigorous test of our understanding of the structure-function relationship—on multiple time and length scales. Accordingly, this research platform holds the promise of expanding our general knowledge with regard to protein folding, molecular interactions, signal transduction and enzyme-catalyzed reactions. Projects in the Wilson Research Group include:
- The development of higher-order biosensors and alternate allosteric communication
- Engineering non-natural protein based electron-transfer systems
- The rational design of temperature-adapted enzyme function
- Engineering oxidation resistant proteins
- The design of functional proteins for carbon nanotube delivery systems
Selected Awards & Honors:
- Chairman and Conference Organizer: 3rd Yale Biophysics & Structural Biology Symposium (2013)
- Keynote Speaker: Claflin University, 3rd Annual Masters Biotechnology Program Open House (2011-2012)
- UCHL Early Achievement Award (2009-2010)
- Gordon Moore Postdoctoral Fellowship at CalTech (2006-2008)
- Schroepfer Award: For Outstanding PhD Thesis (2005)
- Schroepfer Award: For Outstanding Published Research (2004-2005)
- Howell, S.C., Inampudiand, K.K., Bean, D.P. and Wilson, C.J. [in press] (2014) Understanding thermal adaptation of enzymes through the multistate rational design and stability prediction of 100 adenylate kinases. Structure
- Meyer, S., Ramot, R., Kishore Inampudi, K., Luo, B., Lin, C., Amere, S., and Wilson, C. J. (2013) Engineering alternate cooperative-communications in the lactose repressor protein scaffold, Protein engineering, design & selection. Protein Engineering Design & Selection 26, 433-443.
- Sivey, J. D., Howell, S. C., Bean, D. J., McCurry, D. L., Mitch, W. A., and Wilson, C. J. (2013) Role of lysine during protein modification by HOCl and HOBr: halogen-transfer agent or sacrificial antioxidant?, Biochemistry 52, 1260-1271.
- Fadel, T.R., Li, N., Shah, S., Look, M., Pfefferle, L. D., Haller, G.L., Justesen, S., Wilson, C.J. ¶, Fahmy, T.M. ¶. (2013) Impact of bundled carbon nanotube on protein adsorption, structure, and function. Small 9, 666-672 (¶ co-corresponding author).
- Beales, P. A., Geerts, N., Inampudi, K. K., Shigematsu, H., Wilson, C. J., and Vanderlick, T. K. (2013) Reversible assembly of stacked membrane nanodiscs with reduced dimensionality and variable periodicity, Journal of the American Chemical Society 135, 3335-3338.
- Ramot, R., Kishore Inampudi, K., and Wilson, C. J. (2012) Lactose repressor experimental folding landscape: fundamental functional unit and tetramer folding mechanisms, Biochemistry 51, 7569-7579.
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