Stuart Campbell

Assistant Professor of Biomedical Engineering
Room / Office: Malone 211
Office Address:
55 Prospect Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208260
New Haven, CT 06520
Phone: (203) 432-4321
Email: stuart.campbell@yale.edu
Degrees:
  • B.S., Washington State University
  • Ph.D., University of California, San Diego

Interests:

Dr. Campbell’s research currently focuses on understanding the mechanisms that underlie genetic forms of heart disease. His laboratory uses both computational and experimental biomechanics approaches to improve quantitative understanding of these diseases and evolve new therapies. On the computational side, Dr. Campbell has developed novel multi-scale models of the heart that integrate genomic, functional, and anatomical data to predict behavior of the intact organ. The quantitative genotype-phenotype relationships represented in these models are then used to generate testable hypotheses that drive experiments. His laboratory is also developing instrumentation to perform high-throughput functional measurements of individual cardiac cells, allowing spatially varying properties within the heart to be more accurately characterized and incorporated into multi-scale models.

Selected Awards & Honors:

  • Stewart Whitman Award, Gill Heart Institute, University of Kentucky (2011)
  • American Heart Association Postdoctoral Fellowship (2011-2012)
  • Gordon Engineering Leadership Award, Jacobs School of Engineering, University of California, San Diego (2009)
  • American Heart Association Predoctoral Fellowship (2008-2009)

Selected Publications:

  • Sheikh F.*, Ouyang K.*, Campbell S.G.*, Lyon R.C., Chuang J., Fitzsimons D., Tangney, J., Hidalgo C.G., Chung C.S., Cheng H., Dalton N.D., Gu Y., Kasahara H., Ghassemian M., Omens J.H., Peterson K.L., Granzier H.L., Moss R.L., McCulloch A.D., and Chen J. (2012). Integrative mouse and computational models link altered myosin kinetics to early events in cardiac disease. Journal of Clinical Investigation122, 1209–1221. * Equal contributions
  • Campbell S.G. and McCulloch A.D. (2011). Multi-Scale Computational Models of Familial Hypertrophic Cardiomyopathy: Genotype to Phenotype. Journal of the Royal Society Interface8, 1550-1561.
  • Campbell S.G., Hatfield P.C., and Campbell K.S. (2011). A Mathematical Model of Muscle Containing Heterogeneous Half-sarcomeres Exhibits Residual Force Enhancement. PLoS Computational Biology7, e1002156.
  • Campbell S.G., Lionetti F.V., Campbell K.S., and McCulloch A.D. (2010). Coupling of Adjacent Tropomyosins Enhances Crossbridge Mediated Cooperative Activation in a Markov Model of the Cardiac Thin filament.Biophysical Journal98, 2254-64.
  • Campbell S.G., Howard E.J., Aguado-Sierra J., Coppola B.A., Omens J.H., Mulligan L.J., McCulloch A.D., and Kerckhoffs, R.C.P. (2009). Effect of Transmurally Heterogeneous Myocyte Excitation-Contraction Coupling on Left Ventricular Electromechanics, Experimental Physiology95, 541-552.
  • Campbell S.G., Flaim S.N., Leem C.H., and McCulloch A.D. (2008). Mechanisms of transmurally-varying myocyte electromechanics in an integrated computational model, Philosophical Transactions of the Royal Society A366, 3361-3380.