Stuart Campbell

Associate Professor of Biomedical Engineering & Cellular and Molecular Physiology
Room / Office: Malone 211
Office Address:
55 Prospect Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208260
New Haven, CT 06520
Phone: (203) 432-4321
Email: stuart.campbell@yale.edu
Degrees:
  • B.S., Washington State University
  • Ph.D., University of California, San Diego

Interests:

Dr. Campbell’s research currently focuses on understanding the mechanisms that underlie genetic forms of heart disease. His laboratory uses both computational and experimental biomechanics approaches to improve quantitative understanding of these diseases and evolve new therapies. On the computational side, Dr. Campbell has developed novel multi-scale models of the heart that integrate genomic, functional, and anatomical data to predict behavior of the intact organ. The quantitative genotype-phenotype relationships represented in these models are then used to generate testable hypotheses that drive experiments. His laboratory is also developing instrumentation to perform high-throughput functional measurements of individual cardiac cells, allowing spatially varying properties within the heart to be more accurately characterized and incorporated into multi-scale models.

Selected Awards & Honors:

  • NSF CAREER Award (2017)
  • Stewart Whitman Award, Gill Heart Institute, University of Kentucky (2011)
  • American Heart Association Postdoctoral Fellowship (2011-2012)
  • Gordon Engineering Leadership Award, Jacobs School of Engineering, University of California, San Diego (2009)
  • American Heart Association Predoctoral Fellowship (2008-2009)

Selected Publications:

  • Sewanan L.R., Moore J.R., Lehman W. and Campbell S.G. (2016). Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling. Frontiers in Physiology. 7:473.
  • Schwan J., Kwaczala A.T., Ryan T.J., Bartulos O., Ren Y., Sewanan L.R., Morris A.H., Jacoby D.L., Qyang Y., and Campbell S.G. (2016). Anisotropic engineered heart tissue made from laser-cut decellularized myocardium. Scientific Reports. 6:32068(1-12).
  • Aboelkassem Y. and Campbell S.G. (2016). Acute optogenetic modulation of cardiac twitch dynamics explored through modeling. Journal of Biomedical Engineering. 138:111005-(1-11).
  • Wang C., Schwan J., and Campbell S.G. (2016). Slowing of Contractile Kinetics by Myosin-Binding Protein C Can Be Explained by Its Cooperative Binding to the Thin Filament. Journal of Molecular and Cellular Cardiology. 96:2-10.
  • Dash B.C., Levi K., Schwan J., Luo J., Bartulos O., Wu H., Qiu C., Yi T., Ren Y., Campbell S.G., Rolle M.W., and Qyang Y. (2016). Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells. Stem Cell Reports. 7:19-28.
  • Moore J.R., Campbell S.G., and Lehman W. (2016). Structural determinants of muscle thin filament cooperativity. Archives of Biochemistry and Biophysics. 594:8-17.
  • Aboelkassem Y., Bonilla J., McCabe K., and Campbell S.G. (2015). Contributions of Ca2+-Independent Thin Filament Activation to Cardiac Muscle Function. Biophysical Journal. 109:2101-2112.
  • Schwan J. and Campbell S.G. (2015). Prospects for in Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes. Biomarker Insights. 10:91-103.
  • Aboelkassem Y., Savic D., Campbell S.G. (2015). Mathematical Modeling of Aortic Valve Dynamics During Systole. Journal of Theoretical Biology. 360:280-288.
  • Kuo I.Y., Kwaczala A.T., Nguyen L., Russell K.S., Campbell S.G., Ehrlich B.E. (2014). Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways. Proceedings of the National Academy of Sciences. 111:16604–16609.