l_niklason

Shuttered labs and social distancing haven’t gotten in the way of two research teams’ efforts to create a ventilator capable of treating multiple patients.

Before scientists develop the bioengineered tissue of tomorrow for treating pulmonary diseases, they need to identify the best methods for growing tissue for artificial trachea and lungs in experiments today.

A new Yale analysis does just that, determining which methods produce tissue cells that are most like the natural cells they would replace.

This story originally appeared in Yale Engineering Magazine.

Laura Niklason, the Nicholas M. Greene Professor in Anesthesia and Biomedical Engineering, has been elected to the National Academy of Engineering (NAE).

Yale doctors have developed a way to create vascular grafts from stem cells that are as strong as the original blood vessels they would replace.

The advance, demonstrated in an animal model, may lead to bioengineered grafts suitable for transplant into any human patient using universally compatible cell lines, said the researchers.

Using sophisticated screening across animal species, researchers at Yale have created a cellular blueprint of the human lung that will make it easier to understand the design principles behind lung function and disease — and to bioengineer new lungs.

The disembodied living lungs in one Yale researcher's lab show that a standalone bioengineered lung is well along the road to reality.

In one of the longest follow-up studies of its kind, researchers found that their specially bioengineered blood vessels evolved into living tissue after human implantation.

From bold investors to company builders, from research scientists to patient advocates, here are nearly three dozen women and men who are driving progress in medicine and the business of keeping us healthy.

One of the holy grails in the field of regenerative medicine is the ability to engineer whole organs in all their complexity, not just pieces of them. Laura Niklason is one of those pushing this boundary. During a visit, I followed one of her postdocs into a refrigerated closet in her Yale University laboratories. He reached out to a shelf and took down a jar.