Jay Humphrey

Jay Humphrey
John C. Malone Professor of Biomedical Engineering and Chair
Room / Office: Malone 212
Office Address:
55 Prospect Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208260
New Haven, CT 06520
Phone: (203) 432-6428
Email: jay.humphrey@yale.edu
Degrees:
  • Ph.D., Georgia Institute of Technology
  • Post-Doc, Johns Hopkins University

Interests:

Vascular Mechanics and Mechanobiology: using genetic, pharmacologic, and surgical models to elucidate mechanisms that underlie diverse vascular diseases; developing theoretical frameworks for understanding vascular disease progression and designing clinical interventions; and using computational models to design and evaluate tissue engineered vascular grafts based on concepts of mechanobiology and immunobiology.

Selected Awards & Honors:

  • Fellow, International Academy of Medical and Biological Engineering. 2019
  • Collen-Francqui Chair – Belgium (Ghent University and KU Leuven), 2018
  • Doctorate Honoris Causa, École Nationale Supérieure des Mines, St. Étienne, France, 2017
  • H.R. Lissner Medal, American Society of Mechanical Engineers
  • Academy of Distinguished Engineering Alumni, Georgia Tech
  • Fellow, American Society of Mechanical Engineers (Bioengineering Division)
  • Regents Professor, Texas A&M University System
  • Fellow, American Institute for Medical and Biological Engineering
  • First Award, National Institutes of Health
  • Presidential Young Investigator Award, National Science Foundation
  • YC Fung Young Investigator Award, American Society of Mechanical Engineering
  • Young Scientist Award, American Society of Biomechanics

Selected Publications:

From 315+:

  • Li G, Wang M, Caulk AW, …, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G (2020) Chronic mTOR activation induces a degradative smooth muscle cell phenotype and aortopathy. J Clin Invest 130:1233-1251.
  • Drews J, Pepper VA, Best CA, Szafron JM, …, +Humphrey JD, +Shinoka T, +Breuer CK (2020) Spontaneous reversal of stenosis in tissue-engineered vascular grafts. Sci Transl Med 12:eaax6919.
  • Murtada S-I, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD (2020) Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchison-Gilford progeria. J R Soc Interface 17: 20200066.
  • Weiss D, Cavinato C, Gray A, Ramachandra AB, Avril S, Humphrey JD, Latorre M (2020) Mechanics-driven mechanobiological mechanisms of arterial tortuosity. Science Advances 6: eabd3574.
  • Ahmadzadeh H, Rausch MK, Humphrey JD (2019) Particle-based computational modeling reveals roles of localized pools of glycosaminoglycans in aortic dissection. J R Soc Interface 15:20180616.
  • Latorre M, Humphrey JD (2019) Mechanobiological stability of soft tissue growth and remodeling. J Math Phys Solid 125: 298-325.
  • Latorre M, Bersi MR, Humphrey JD (2019) Computational modeling predicts immuno-mechanical mechanisms of maladaptative aortic remodeling in hypertension. Int J Engr Sci 14: 35-46.
  • Ambrosi D, Ben Amar M, Cyron CJ, DeSimona A, Goriely A, +Humphrey JD, +Kuhl E (2019) Growth and remodeling of living systems: Perspectives, challenges, and opportunities. J R Soc Interface 16: 20190233.
  • Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD (2018) Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomech Model Mechanobiol 17: 1281-1295.
  • Bhagavan D, Di Achille P, Humphrey JD (2018) Strongly coupled morphological features of aortic aneurysms drive intraluminal thrombus. <em">Sci Reports 8: 13273.
  • Bellini C, Bersi MR, Caulk A, Ferruzzi J, Milewicz DM, Ramirez F, Rifkin DB, Tellides G, Yanagisawa H, Humphrey JD (2017) Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms. J R Soc Interface 14:20161036.
  • Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G (2017) mTOR (mechanistic target of rapamycin) inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the thoracic aorta in elastin-deficient mice. ATVB 37: 1657-1666.
  • Bersi MR, Bellini C, Wu J, Harrison DG, Humphrey JD (2016) Excessive adventitial remodeling leads to early aortic maladaptation in angiotensin-induced hypertension. Hypertension 67: 890-896.
  • Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S (2016) Central artery stiffness in hypertension and aging: A problem with cause and consequence. Circ Res 118: 379-381.
  • Miller KS, Khosravi R, Breuer CK, Humphrey JD (2015) A hypothesis-driven parametric study of the effects of polymeric scaffold properties on tissue engineered neovessel formation. Acta Biomater 11: 283-294.
  • Bellini C, Wang S, Milewicz DM, Humphrey JD (2015) Myh11R247C/R247C mutations increase thoracic aortic vulnerability to intramural damage despite a general biomechanical adaptivity. J Biomech 48: 113-121.
  • Humphrey JD, Milewicz DM, Tellides G, Schwartz MA (2014) Dysfunctional mechanosensing in aneurysms. Science 344: 477-479.
  • Humphrey JD, Dufrense E, Schwartz MA (2014) Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 15: 802-812.

Additional Positions:

  • Member, World Council of Biomechanics (2006-2018)
  • Chair, US National Committee of Biomechanics (2014-2016)
  • Program Chair, 2014 World Congress of Biomechanics
  • Co-Editor in Chief, Biomechanics and Modeling in Mechanobiology (2001-2011)

Books:

  • Humphrey JD and O'Rourke SL. An Introduction to Biomechanics: Solids and Fluids, Analysis and Design. 2nd Edition. Springer, NY, 2015 (1st Edition, 2004).
  • Humphrey JD and Holmes JW. Style and Ethics of Communication in Science and Engineering. Morgan & Claypool, CO, 2009.
  • Humphrey JD. Cardiovascular Solid Mechanics: Cells, Tissues, and Organs. Springer-Verlag, NY, 2002.
  • Cowin SC and Humphrey JD (editors). Cardiovascular Soft Tissue Mechanics, Kluwer, Netherlands, 2002.