Jay Humphrey

Jay Humphrey
John C. Malone Professor of Biomedical Engineering and Chair
Room / Office: Malone 212
Office Address:
55 Prospect Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208260
New Haven, CT 06520
Phone: (203) 432-6428
Email: jay.humphrey@yale.edu
  • Ph.D., Georgia Institute of Technology
  • Post-Doc, Johns Hopkins University


Vascular Mechanics and Mechanobiology: using genetic, pharmacologic, and surgical models to elucidate mechanisms that underlie diverse vascular diseases; developing theoretical frameworks for understanding vascular disease progression and designing clinical interventions; and using computational models to design and evaluate tissue engineered vascular grafts based on concepts of mechanobiology and immunobiology.

Selected Awards & Honors:

  • Fellow, International Academy of Medical and Biological Engineering. 2019
  • Collen-Francqui Chair – Belgium (Ghent University and KU Leuven), 2018
  • Doctorate Honoris Causa, École Nationale Supérieure des Mines, St. Étienne, France, 2017
  • H.R. Lissner Medal, American Society of Mechanical Engineers
  • Academy of Distinguished Engineering Alumni, Georgia Tech
  • Fellow, American Society of Mechanical Engineers (Bioengineering Division)
  • Regents Professor, Texas A&M University System
  • Fellow, American Institute for Medical and Biological Engineering
  • First Award, National Institutes of Health
  • Presidential Young Investigator Award, National Science Foundation
  • YC Fung Young Investigator Award, American Society of Mechanical Engineering
  • Young Scientist Award, American Society of Biomechanics

Selected Publications:

From 285+:

  • Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD (2018) Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomech Model Mechanobiol (ePub ahead of print).
  • Bhagavan D, Di Achille P, Humphrey JD (2018) Strongly coupled morphological features of aortic aneurysms drive intraluminal thrombus. Sci Reports 8: 13273.
  • Bellini C, Bersi MR, Caulk A, Ferruzzi J, Milewicz DM, Ramirez F, Rifkin DB, Tellides G, Yanagisawa H, Humphrey JD (2017) Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms. J R Soc Interface 14:20161036.
  • Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G (2017) mTOR (mechanistic target of rapamycin) inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the thoracic aorta in elastin-deficient mice. ATVB 37: 1657-1666.
  • Bersi MR, Bellini C, Wu J, Harrison DG, Humphrey JD (2016) Excessive adventitial remodeling leads to early aortic maladaptation in angiotensin-induced hypertension. Hypertension 67: 890-896.
  • Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S (2016) Central artery stiffness in hypertension and aging: A problem with cause and consequence. Circ Res 118: 379-381.
  • Miller KS, Khosravi R, Breuer CK, Humphrey JD (2015) A hypothesis-driven parametric study of the effects of polymeric scaffold properties on tissue engineered neovessel formation. Acta Biomater 11: 283-294.
  • Bellini C, Wang S, Milewicz DM, Humphrey JD (2015) Myh11R247C/R247C mutations increase thoracic aortic vulnerability to intramural damage despite a general biomechanical adaptivity. J Biomech 48: 113-121.
  • Humphrey JD, Milewicz DM, Tellides G, Schwartz MA (2014) Dysfunctional mechanosensing in aneurysms. Science 344: 477-479.
  • Humphrey JD, Dufrense E, Schwartz MA (2014) Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 15: 802-812.

Additional Positions:

  • Member, World Council of Biomechanics (2006-2018)
  • Chair, US National Committee of Biomechanics (2014-2016)
  • Program Chair, 2014 World Congress of Biomechanics
  • Co-Editor in Chief, Biomechanics and Modeling in Mechanobiology (2001-2011)


  • Humphrey JD and O'Rourke SL. An Introduction to Biomechanics: Solids and Fluids, Analysis and Design. 2nd Edition. Springer, NY, 2015 (1st Edition, 2004).
  • Humphrey JD and Holmes JW. Style and Ethics of Communication in Science and Engineering. Morgan & Claypool, CO, 2009.
  • Humphrey JD. Cardiovascular Solid Mechanics: Cells, Tissues, and Organs. Springer-Verlag, NY, 2002.
  • Cowin SC and Humphrey JD (editors). Cardiovascular Soft Tissue Mechanics, Kluwer, Netherlands, 2002.