Graeme Mason

Professor of Radiology & Biomedical Imaging, Psychiatry & Biomedical Engineering
Office Address:
300 Cedar Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208043
New Haven, CT 06520
Phone: (203) 737-1478
  • Ph.D., Yale University
  • B.S., The Pennsylvania State University


Dr. Graeme F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry in conjunction with 13C isotopic labeling in vivo, in cell preparations, and other systems. His work began during his graduate studies at Yale where he used a rat model for the experimental determination of brain glucose transport kinetics, energetics, and neurotransmitter metabolism. Dr. Mason received further training at the University of Alabama at Birmingham, where he guided the group's 13C-labeling studies of the human brain in vivo in the 4.1T whole-body MR system. Dr. Mason studies metabolism and neurotransmission in the brain in vivo, including effects of psychiatric disorders and substances such as alcohol and nicotine; Dr. Mason examines healthy subjects and patients to investigate relationships among GABA, glutamate, and glutamine concentrations and their rates of synthesis and release in the brain, in particular with regard to effects of acute and chronic use of alcohol.  He also studies detailed kinetic modeling of isotopomer and isotopologues using data from high-resolution NMR and mass spectrometry.

Selected Awards & Honors:

  • Inducted into the Academy Distinguished Investigator Council, Academy for Radiology & Biomedical Imaging Research (2018)
  • Editor's Recognition for Reviewing, Biological Psychiatry (2016)
  • Elected Fellow, American College of Neuropsychopharmacology (2015)
  • Elected Senior Fellow, International Society of Magnetic Resonance in Medicine (2015)
  • Editor's Recognition for Reviewing, Biological Psychiatry (2015)
  • Editor's Recognition for Reviewing, Biological Psychiatry (2014)
  • Editor's Recognition for Reviewing Biological Psychiatry (2012)
  • Editor's Recognition for Reviewing Biological Psychiatry (2011)
  • Editor's Recognition for Reviewing Biological Psychiatry (2009)

Selected Publications:

  • Hwang JJ, Jiang L, Rangel ES, Fan X, Ding Y, Lam W, Leventhal J, Dai F, Rothman DL, Mason GF, Sherwin RS (2019) Glycemic variability and brain glucose levels in type 1 diabetes.  Diabetes 68: 163-171.
  • Abdallah CG, Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF (2018) The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.  Neuropsychopharmacol 43: 2154–2160
  • Wang J, Du H, Jiang L, Ma X, de Graaf R, Behar K, Mason GF (2013) Oxidation and Effects of Ethanol in the Rat Brain after Chronic Ethanol Exposure.  Proc Natl Acad Sci USA 110: 14444-14449