Chenxiang Lin

Website:

Lin Lab

Associate Professor of Cell Biology and Biomedical Engineering

Room / Office: Rm 213

Office Address:

850 West Campus Drive

West Haven, CT 06516

Mailing Address:

P.O. Box 27396

West Haven, CT 06516

Phone: (203) 737-3924

Email: chenxiang.lin@yale.edu

Degrees:

Ph.D., Arizona State University
B.S., Peking University

Interests:

Nature has evolved sophisticated and highly efficient molecular machineries for all forms of lives. Our lab focuses on engineering DNA-nanostructure-based molecular tools for investigating and engineering the naturally occurring molecular events. Those DNA-based tools have made it possible for us to manipulate macromolecules and higher order assemblies with nanometer precision. We expect such research to help elucidate biological questions at the single-molecule level, and in the long run lead to functional synthetic nano-machines that rival natural systems in complexity.

Research themes in our lab include:

Structural DNA Nanotechnology: rational design of self-assembled DNA nanostructure with ever-increasing complexity and size.
Single-Molecule Biophysics: study of biomolecule interactions through DNA-directed self-assembly and other single-molecule techniques.
Biosensing and Imaging: developing nucleic-acid-based barcodes as multiplexed biosensors and/or in situ imaging probes.
Synthetic Biology: rebuild naturally existing machineries (e.g., SNARE complex, nuclear pore, etc.) with artificial components and/or spatial arrangement.

Selected Awards & Honors:

Odyssey Award, Richard and Susan Smith Family Foundation (2020)
Director's New Innovator Award, National Institutes of Health (2014)

Selected Publications:

Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Yang Y, Wu Z, Wang L, Zhou K, Xia K, Xiong Q, Liu L, Zhang Z, Chapman ER, Xiong Y, Melia TJ, Karatekin E, Gu H, Lin C. Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Nature Chemistry 2021, 13:335-342.
A Programmable DNA-Origami Platform for studying lipid transfer between bilayers. Bian X, Zhang Z, Xiong Q, De Camilli P, Lin C. A programmable DNA-origami platform for studying lipid transfer between bilayers. Nature Chemical Biology 2019, 15:830-837.
A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement. Fisher PDE, Shen Q, Akpinar B, Davis LK, Chung KKH, Baddeley D, Saric A, Melia TJ, Hoogenboom BW, Lin C, Lusk CP. A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement. ACS Nano 2018, 12:1508-1518.
Vesicle Tubulation with Self-Assembling DNA Nanosprings. Grome MW, Zhang Z, Pincet F, Lin C. Vesicle Tubulation with Self-Assembling DNA Nanosprings. Angewandte Chemie (International Ed. In English) 2018, 57:5330-5334.
Placing and shaping liposomes with reconfigurable DNA nanocages. Zhang Z, Yang Y, Pincet F, C Llaguno M, Lin C. Placing and shaping liposomes with reconfigurable DNA nanocages. Nature Chemistry 2017, 9:653-659.
Self-assembly of size-controlled liposomes on DNA nanotemplates. Yang Y, Wang J, Shigematsu H, Xu W, Shih WM, Rothman JE, Lin C. Self-assembly of size-controlled liposomes on DNA nanotemplates. Nature Chemistry 2016, 8:476-83.
Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Lin C, Jungmann R, Leifer AM, Li C, Levner D, Church GM, Shih WM, Yin P. Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Nature Chemistry 2012, 4:832-9.
In vivo cloning of artificial DNA nanostructures. Lin C, Rinker S, Wang X, Liu Y, Seeman NC, Yan H. In vivo cloning of artificial DNA nanostructures. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105:17626-31.