Chenxiang Lin


Lin Lab
Associate Professor of Cell Biology and Biomedical Engineering
Room / Office: Rm 213
Office Address:
850 West Campus Drive
West Haven, CT 06516
Mailing Address:
P.O. Box 27396
West Haven, CT 06516
Phone: (203) 737-3924
  • Ph.D., Arizona State University
  • B.S., Peking University


Nature has evolved sophisticated and highly efficient molecular machineries for all forms of lives. Our lab focuses on engineering DNA-nanostructure-based molecular tools for investigating and engineering the naturally occurring molecular events. Those DNA-based tools have made it possible for us to manipulate macromolecules and higher order assemblies with nanometer precision. We expect such research to help elucidate biological questions at the single-molecule level, and in the long run lead to functional synthetic nano-machines that rival natural systems in complexity.

Research themes in our lab include:

  1. Structural DNA Nanotechnology: rational design of self-assembled DNA nanostructure with ever-increasing complexity and size.
  2. Single-Molecule Biophysics: study of biomolecule interactions through DNA-directed self-assembly and other single-molecule techniques.
  3. Biosensing and Imaging: developing nucleic-acid-based barcodes as multiplexed biosensors and/or in situ imaging probes.
  4. Synthetic Biology: rebuild naturally existing machineries (e.g., SNARE complex, nuclear pore, etc.) with artificial components and/or spatial arrangement.

Selected Awards & Honors:

  • Odyssey Award, Richard and Susan Smith Family Foundation (2020)
  • Director's New Innovator Award, National Institutes of Health (2014)

Selected Publications: