Ansel Hillmer

Assistant Professor of Radiology & Biomedical Imaging, Psychiatry & Biomedical Engineering
Office Address:
2 Church Street South
New Haven, CT
06511
Mailing Address:
P.O. Box 208043
New Haven, CT
06520
Email: ansel.hillmer@yale.edu
Degrees:
- Ph.D., University of Wisconsin, Madison
- M.S., University of Wisconsin, Madison
- B.S., Valparaiso University
Interests:
I am interested in implementing neurochemically specific brain imaging techniques, such as positron emission tomography (PET), to investigate the underlying neuroadaptations involved in substance dependence and withdrawal, particularly alcohol and nicotine. Areas of previous and current research include:
- Characterization of PET imaging radiotracers targeting alpha4beta2 nicotinic acetylcholine receptors, alpha7 nicotinic acetylcholine receptors, and serotonin 5-HT1A receptors
- Development of experimental paradigms to interrogate acetylcholine neurotransmission in vivo with PET imaging
- Using PET imaging the study the neurochemistry of chronic alcohol use in nonhuman primate models
- Imaging neuroinflammation in clinical alcohol dependence
- Methods development of analysis tools integrating PET imaging data with fMRI connectivity data
- Studying alpha7 nicotinic acetylcholine receptors in PTSD
Selected Publications:
- Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence. Molecular Psychiatry 2017, 22:1759-1766.
- Hillmer AT, Li S, Zheng MQ, Scheunemann M, Lin SF, Nabulsi N, Holden D, Pracitto R, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Esterlis I, Cosgrove KP, Brust P, Carson RE, Huang Y. PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans. European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44:1042-1050.
- Hillmer AT, Esterlis I, Gallezot JD, Bois F, Zheng MQ, Nabulsi N, Lin SF, Papke RL, Huang Y, Sabri O, Carson RE, Cosgrove KP. Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (-)-[(18)F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain. NeuroImage 2016, 141:71-80.
- Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Alcoholism, Clinical And Experimental Research 2016, 40:698-705.
- Hillmer AT, Wooten DW, Slesarev MS, Ahlers EO, Barnhart TE, Schneider ML, Mukherjee J, Christian BT. Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [(18)F]nifene PET in the nonhuman primate. Journal Of Cerebral Blood Flow And Metabolism:Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2013, 33:1806-14.