Andrew D. Miranker

Andrew Miranker


Miranker Lab
Professor of Molecular Biophysics & Biochemistry and Chemical & Environmental Engineering
Room / Office: Bass 318
Office Address:
266 Whitney Avenue
New Haven, CT 06511
Mailing Address:
P.O. Box 208114
New Haven, CT 06520
Phone: (203) 432-8954
  • Ph.D., Harvard University


Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils.

Selected Publications:

  • Kumar S, Brown MA, Nath A, Miranker AD. (2014) Folded Small Molecule Manipulation of Islet Amyoid Polypeptide. Chem Biol. 
  • Last NB, Schlamadinger DE, Miranker AD. (2013) A common landscape for membrane-active proteins. Protein Sci. 7, 870-82.
  • Kumar S, Miranker AD. (2013) A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide. Chem. Commun. 49, 4749-4751. 
  • Last NB, Miranker AD. (2013) Common mechanism unites membrane poration by amyloid and antimicrobial peptides. Proc Natl Acad Sci U S A. 110(16):6382-7. 
  • Magzoub M, Miranker AD. (2012) Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide. FASEB J. 26(3):1228-38. 
  • Nath A, Miranker AD, Rhoades E. (2011) A membrane-bound antiparallel dimer of rat islet amyloid polypeptide. Angew Chem Int Ed Engl. 50(46):10859-62. 
  • Last NB, Rhoades E, Miranker AD. (2011) Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity. Proc Natl Acad Sci U S A. 108(23):9460-5. 
  • Magzoub M, Miranker AD. (2011) Protein aggregation: p53 succumbs to peer pressure. Nat Chem Biol. 7(5):248-9.