Albert J. Sinusas
- M.D., University of Vermont College of Medicine
- B.Sc., Rensselaer Polytechnic Institute
Interests:
My research is directed at development, validation and application of non-invasive imaging approaches for the assessment of cardiovascular pathophysiology, including; targeted molecular assessment of myocardial ischemia, angiogenesis, arteriogenesis, atrial and ventricular remodeling, and peripheral artery disease. This translational research employs the 3–D modalities of SPECT/CT, PET/CT, X-ray computed tomography (CT), fluoroscopy and cone-beam CT, echocardiography, and MR imaging in both patients and a wide range of animal models, including rodent and large animal models. My laboratory is currently focused on the evaluation of the intramyocardial delivery of theranostic hydrogels to the heart for prevention of post infarction cardiac remodeling, and application of targeted imaging of integrins and matrix metalloproteinases in evaluation of cardiac remodeling. I co-direct a T32 grant for “Training in multi-modality molecular and translational cardiovascular imaging”. My laboratory is developing and applying multimodality cardiovascular and molecular imaging in pre-clinical and translational research, and first-in-human studies.
Selected Publications:
- Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T-W, Spinale FG, Sinusas AJ. Application of Hybrid MMP-Targeted and Dynamic Tl-201 SPECT/CT Imaging for Evaluation of Early Post Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging, 2019 12(11):e009055. doi: 10.1161/CIRCIMAGING.119.009055. PMID: 31707811
- Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MA, French BA, Annex BH, Carrasco N, Sinusas AJ. Non-invasive in vivo quantification of AAV9-mediated expression of the sodium/iodide Symporter (NIS) under hind-limb ischemia and neuraminidase desialylation in skeletal muscle using SPECT/CT. Circulation Cardiovascular Imaging, 2019, 12(7):e009063. doi:10.1161/ CIRCIMAGING.119.009063. PMID: 31296047
- Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC Cardiovasc Imaging. 2018 Oct 12. pii: S1936-878X(18)30755-1. PMID: 30343093
- Parajuli N, Lu A, Ta K, Stendahl J, Boutagy N, Alkhalil I, Eberle M, Jeng GS, Zontak M, O'Donnell M, Sinusas AJ, Duncan JS. Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis. Med Image Anal. 2019; 55:116-135. PMID: 31055125