W. Mark Saltzman

Goizueta Foundation Professor of Biomedical Engineering, Chemical & Environmental Engineering & Physiology
Room / Office: Malone 413
Office Address:
55 Prospect Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208260
New Haven, CT 06520
Phone: (203) 432-3281
Fax: (203) 432-0030
Email: mark.saltzman@yale.edu
Degrees:
  • Ph.D., Harvard/MIT Division of Health Science and Technology
  • S.M., Massachusetts Institute of Technology
  • B.S., Iowa State University

Interests:

Saltzman's research is motivated by the desire to create safer and more effective medical and surgical therapy. He focuses on tissue engineering and on creating better methods for drug delivery. His group has developed technology based on the use of bio-compatible polymeric materials for the controlled delivery of drugs, proteins, and genes. They have also developed new polymeric materials that influence the growth and assembly of tissues. However, even better than treating disease is to prevent disease from occurring in the first place. Saltzman's intent, therefore, is to develop the most economical, transportable, and accessible methods for disease prevention.

Saltzman is also committed to training a new generation of chemical and biomedical engineers. He believes in providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative blending of technology and modern biological science.

Selected Awards & Honors:

  • Fellow, National Academy of Inventors (2013)
  • Fellow, Biomedical Engineering Society (2010)
  • Sheffield Teaching Prize, Yale University (2009)
  • Paper selected as one of top 25 published over past 25 years in Biomaterials (2006)
  • Distinguished Lecturer Award, Biomedical Engineering Society (2004)
  • BP Amoco/H.Laurence Fuller Chair in Chemical Engineering at Cornell (2001)
  • Britton Chance Distinguished Lecturer in Engineering and Medicine, at the University of Pennsylvania (2000)
  • Professional Progress in Engineering Award from Iowa State University (2000)
  • Member, Surgery & Bioengineering Study Section (NIH) (1999)
  • Richard Tucker Excellence in Teaching Award (Cornell) (1999)
  • Fellow, American Institute for Medical and Biological Engineering (1997)
  • Controlled Release Society Young Investigator Award (1996)
  • Allan C. Davis Medal as Maryland's Outstanding Young Engineer (1995)
  • Distinguished Faculty Award for Excellence in Undergraduate Education (Johns Hopkins) (1995)
  • Camille and Henry Dreyfus Foundation Teacher-Scholar Award. (1990)

Selected Publications:

  • Liu J, Jiang Z, Zhang S, and Saltzman WM. Poly(ω-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery, Biomaterials 30:5707-5719 (2009).
  • Cartiera MS, Ferreira EC, Caputa C, Egan ME, Caplan MJ, and Saltzman WM. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin, Molecular Pharmaceutics 7: 86-93 (2010).
  • Jay SM, Shepherd BR, Andrejecsk JW, Kyriakides TR, Pober JS, and Saltzman WM. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization, Biomaterials 31:3054-3062 (2010).
  • Rubin J, Paltiel AD, and Saltzman WM. Are we studying what matters? Health priorities and NIH-funded biomedical engineering research. Annals of Biomedical Engineering 38:2237-2251 (2010).
  • McNeer, NA, Chin JY, Schleifman EB, Fields RJ, Glazer PM, and Saltzman WM. Nanoparticles delivery triplex-forming PNA for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Molecular Therapy 19:172-180 (2011).
  • Liu J, Jiang Z, Zhou J, Zhang S, and Saltzman WM. Enzymatic synthesized poly(amine-co-esters) as non-viral vectors for gene delivery, Journal of Biomedical Materials Research A 96A:456-465 (2011).
  • Sawyer AJ, Saucier-Sawyer J, Booth C, Liu J, Patel T, Piepmeier JM, and Saltzman WM. Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors, Drug Delivery and Translational Research 1:34-42 (2011).

Books:

  • Drug Delivery: Engineering Principles for Drug Therapy, 2001, Published by Oxford University Press.
  • Tissue Engineering: Engineering principles for the design of replacement organs and tissues, 2004, Published by Oxford University Press.
  • Biomedical Engineering: Bridging Medicine and Technology2009, Published by Cambridge University Press.