Martin A. Schwartz

Martin Schwartz


Schwartz Lab
Robert W. Berliner Professor of Medicine (Cardiology), Cell Biology & Biomedical Engineering
Office Address:
15 York Street
New Haven, CT 06510
Mailing Address:
P.O. Box 208017
New Haven, CT 06520
Phone: (203) 737-2930
  • B.A., New College of the University South Florida
  • Ph.D., Stanford University


Integrin signaling; Mechanotransduction; Atherosclerosis; Vascular remodeling; Heart disease; Extracellular matrix; Cell adhesion; Cytoskeleton; Cell-cell junctions; Fluid shear stress.

Selected Awards & Honors:

  • Hayashi Lecturer, Woods Hole MBL Physiology Course; Marine Biology Laboratory (2009)
  • James O. Davis Lectureship; University of Missouri (2009)
  • Robert W. Berliner Professor of Medicine; Yale School of Medicine (2012)
  • Harold F. Dvorak Plenary Lecture; Harvard Medical School (2013)
  • Andrew P. Somlyo Honorary Lecture; Pennsylvania Muscle Institute, University of Pennsylvania (2013)

Selected Publications:

  • Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1. Curr Biol. 2013 Jun 3, 23:1024-30
  • Hoffman, B.D., Grashoff, C. and Schwartz, M.A. Dynamic molecular processes mediate cellular mechanotransduction. Nature. 2011, 475:316-323.
  • Grashoff C., Hoffman BD., Brenner MD., Zhou R., Parsons M., Yang MT., McLean MA., Sligar SG., Chen CS., Ha T. and Schwartz, MA.. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature, 2010,466:263-6.
  • Orr, A.W., Stockton, R., Simmers,M.B., Sanders, J.M., Sarembock, I.J., Blackman, B.R., Schwartz, M.A. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J Cell Biol. 2007, 176:719-727.
  • Balasubramanian, N., Scott, D.W., Castle, J.D., Casanova, J.E., Schwartz, M.A. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nat Cell Biol. 2007, 9:1381-1391.
  • Tzima, E, Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G., DeLisser, H., Schwartz, M. A. Identification of a mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005, 437:426-430.