Kathryn Miller-Jensen

Kathryn Miller-Jensen


Lab Website
Associate Professor of Biomedical Engineering & Molecular, Cellular & Developmental Biology
Room / Office: Malone 311
Office Address:
55 Prospect Street
New Haven, CT 06511
Mailing Address:
P.O. Box 208260
New Haven, CT 06520
Phone: (203) 432-4265
Email: kathryn.miller-jensen@yale.edu
  • Ph.D., Massachusetts Institute of Technology
  • A.B., B.E., Dartmouth College


Cells interpret and respond to environmental cues using a signaling network comprising chemical and physical interactions between molecules that, ultimately, modulate cellular behavior. During viral infection, these signaling networks are "hijacked" and rewired by virus proteins in order to induce a state of viral pathogenesis. Dr. Miller-Jensen’s group applies quantitative, systems-level approaches to study signaling aspects of viral infection and develop novel anti-viral therapies. Her lab uses genetically-engineered viruses to study viral infection, as well as experimental and computational techniques for monitoring changes in the signaling network induced by these infections. She is currently interested in studying how proteins expressed in early-stage HIV infections establish a pathogenic state in cells of the immune system, and how latent HIV can be reactivated to purge chronic infections.

Selected Awards & Honors:

  • NRSA Postdoctoral Fellowship, National Institutes of Health (2008-2011)
  • Postdoctoral Fellowship, California AIDS Research Program (declined)
  • Science & Technology Policy Fellow, The National Academies (2006)
  • Biotechnology Training Grant, National Institutes of Health (2001-2004)
  • Clare Boothe Luce Fellow, Thayer School of Engineering (1997-1998)

Selected Publications:

  • Burnett, J.C., Miller-Jensen, K., Shah, P.S., Arkin, A.P., Schaffer, D.V (2009). Control of stochastic gene expression by host factors at the HIV promoter, PLoS Pathogens, 5(1): e1000260. 
  • Miller-Jensen, K.*, Janes, K.A.*, Brugge, J. S., Lauffenburger, D.A. (2007). Common effector processing mediates cell-specific responses to stimuli, Nature, 448, 604-8. (Research highlight in Nature Biotechnology, 9/07
  • Miller-Jensen, K., Janes, K.A., Wong, Y., Griffith, L.G., Lauffenburger, D.A. (2006). Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis, J Cell Science, 119, 3788-98.