D.S. Fahmeed Hyder

D.S. Fahmeed Hyder
Professor of Biomedical Engineering & Diagnostic Radiology
Room / Office: TAC N143
Office Address:
300 Cedar Street
New Haven, CT 06519
Mailing Address:
P.O. Box 208043
New Haven, CT 06520
Phone: (203) 785-6205
Email: fahmeed.hyder@yale.edu
Degrees:

Ph.D., Yale University

Interests:

The societal burden of misdiagnosed brain disorders and diseases is substantial. The Hyder lab is leading breakthroughs in quantitative and translational imaging technologies, based primarily on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level. A primary interest in my laboratory is to develop functional imaging techniques that relate neural activity to underlying laminar structure in health and disease. Another active interest in my laboratory is molecular imaging with magnetic resonance technologies where several disciplines connect, from chemistry and physics to material science and physiology.

Selected Awards & Honors:

  • Pilot Award, Yale-UCL Medical Technologies Collaborative: Imaging & Sensing (2013)
  • Pilot Award, Juvenile Diabetes Research Foundation (2008) 
  • Niels Lassen Award, International Society for Cerebral Blood Flow and Metabolism (2003) 
  • 21st Century Science Initiative Grant: James S. McDonnell Foundation (2001) 
  • Melvin H. Knisely Award, International Society on Oxygen Transport to Tissue (2001) 
  • Early Career Faculty Award, National Science Foundation & National Institutes of Health (1998)

Selected Publications:

Mathematical Modeling of Complex Brain Systems

  • Hyder F, Rothman DL, Bennett MW (2013) Cortical energy demands of signaling and non-signaling components are conserved across mammalian species and activity levels. Proc Natl Acad Sci USA. 110:3549-3554
  • Hyder F, Fulbright RK, Shulman RG, Rothman DL (2013) Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy. J Cereb Blood Flow Metab. 33:339-347

Physiology & Metabolism of Brain Function (Calibrated fMRI)

  • Herman P, Sanganahalli BG, Blumenfeld H, Rothman DL, Hyder F (2013) Quantitative basis for neuroimaging of cortical laminae with calibrated fMRI. Proc Natl Acad Sci USA. 110:15115-15120
  • Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F (2013) Analysis of time and space invariance of BOLD responses in the rat visual system. Cereb Cortex. 23:210-222

Molecular Imaging & Biosensing (Probes, Methods)

  • Palchoudhury S, Hyder F, Vanderlick TK, Geerts N (2014) Water-soluble anisotropic iron oxide nanoparticles: dextran coated nanoplates and nanoflowers of high crystallinity. Particul Sci Tech. (in press)
  • Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F (2014) Localized detection of fluoro-deoxy-glucose metabolism in rat brain by 19F chemical shift imaging. Magn Reson Imag. (in press)
  • Coman D, de Graaf RA, Rothman DL, Hyder F (2013) In vivo three-dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR Biomed. 26:1589-1595

Neuroanatomy in Health & Disease (DTI, Behavior)

  • Scafidi J, Roncal M, Jablonska B, Coman D, Huang Y, Hammond T, Szigeti-Buck K, Hyder F, Horvath TL, McCarter Jr. RJ, Gallo V (2014) Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature. (in press)
  • van Luijtelaar G, Mishra AM, Edelbroek P, Coman D, Frankenmolen N, Schaapsmeerders P, Covolato G, Danielson N, Niermann H, Janeczko K, Kiemeneij A, Burinov J, Bashyal C, Coquillette M, Luttjohann A, Hyder F, Blumenfeld H, van Rijn CM (2013) Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiol Dis. 60:126-138

Neuroimaging in Health & Disease (fMRI, Electrophysiology)

  • Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F (2013) Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage. 79:404-411
  • Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS (2013) Mitochondrial calcium uptake capacity modulates neocortical excitability. J Cereb Blood Flow Metab. 33:1115-1126
  • Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS (2013) Mitochondrial modulation of spontaneous neocortical activity: Implications for resting state fMRI of neuropathology. PLoS ONE. 8(5):e63317
  • Mishra AM, Bai X, Motelow JE, DeSalvo M, Danielson N, Sanganahalli BG, Hyder F, Blumenfeld H (2013) Increased resting functional connectivity in spike-wave epilepsy in WAG/Rij rats. Epilepsia. 54:1214-1222

Metabolism in Health & Disease (MRS, PET)

  • Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL (2013) Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. J Clin Invest. 123:1988-1998

High-Resolution Imaging of Systems Neuroscience (fMRI)

  • Sanganahalli BG, Bailey CJ, Herman P, Hyder F (2009) Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents. Methods Mol Biol. 489:213-242