Corey S. O'Hern

Associate Professor of Mechanical Engineering & Materials Science, Physics, Applied Physics & Graduate Program in Computational Biology & Bioinformatics
Room / Office: Mason 203
Office Address:
9 Hillhouse Avenue
New Haven, CT 06511
Mailing Address:
P.O. Box 208286
New Haven, CT 06520
Phone: (203) 432-4258
Email: corey.ohern@yale.edu
Degrees:

Ph.D., University of Pennsylvania

Interests:

Statistical mechanics of nonequilibrium systems; glass and jamming transitions in soft matter; computational biology; protein structure, interactions, and design.

Selected Awards & Honors:

  • Faculty Early Career Development Award from the National Science Foundation (2005)
  • Cyber-Enabled Discover and Innovation Award from the National Science Foundation (2008)

Selected Publications:

  • D. Caballero, A. Virrueta, C. S. O'Hern, and L. Regan, ''Steric interactions determine side chain conformations in protein cores,'' Protein Eng. Des. Sel. 29 (2016) 367.
  • T. Bertrand, R. P. Behringer, B. Chakraborty, C. S. O'Hern, and M. D. Shattuck, ''Protocol dependence of the jamming transition,'' Phys. Rev. E 93 (2016) 012901; xxx.lanl.gov/abs/1506.05041
  • A. Virrueta, C. S. O'Hern, and L. Regan, ''Understanding the physical basis for the side chain conformational preferences of methionine,'' Proteins: Structure, Function, and Bioinformatics 84 (2016) 900.
  • J. Gaines, W. W. Smith, L. Regan, and C. S. O'Hern, ''Random close packing in protein cores,'' Phys. Rev. E 93 (2016) 032415; xxx.lanl.gov/abs/1510.04306
  • K. Zhang, M. Fan, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Beyond packing of hard spheres: The effects of core softness, non-additivity, intermediate-range repulsion, and many-body interactions on the glass-forming ability of bulk metallic glasses,'' J. Chem. Phys. 143 (2015) 184502; xxx.lanl.gov/abs/1509.04731
  • K. Wang, S. Langevin, C. S. O'Hern, M. D. Shattuck, R. Slayden, M. Katze, and M. Kirby, ''Anomaly detection in host signaling pathways for the early prognosis of acute infection,'' PloS ONE 11 (2016) e0160919.
  • Y. Rokhlenko, M. Gopinadhan, C. O. Osuji, K. Zhang, C. S. O'Hern, S. R. Larson, P. Gopalan, P. W. Majewski, and K. G. Yager, ''Magnetic alignment of block copolymer microdomains by intrinsic chain anisotropy'' Phys. Rev. Lett. 115 (2015) 258302.
  • K. Zhang, B. Dice, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''On the origin of multi-component bulk metallic glasses: Atomic size mismatches and demixing'' J. Chem. Phys. 143 (2015) 054501; xxx.lanl.gov/abs/1505.06771
  • A. H. Clark, M. D. Shattuck, N. T. Ouellette, and C. S. O'Hern, ''Onset and cessation of motion in hydrodynamically sheared granular beds,'' Phys. Rev. E 92 (2015) 042202; xxx.lanl.gov/abs/1504.03403
  • L. Regan, D. Caballero, M. R. Hinrichsen, A. Virrueta, D. M. Williams, and C. S. O'Hern, ''Protein Design: Past, Present, and Future,'' Biopolymers: Peptide Science 104 (2015) 334.
  • K. Zhang, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''The glass-forming ability of model metal-metalloid alloys,'' J. Chem. Phys. 142 (2015) 104504; xxx.lanl.gov/abs/1412.0766
  • D. Caballero, W. W. Smith, C. S. O'Hern, and L. Regan, ''Equilibrium transitions between side chain conformations in Leu and Ile,'' Proteins: Structure, Function, and Bioinformatics 83 (2015) 1488.
  • M. Wang, K. Zhang, Z. Li, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Asymmetric crystallization during cooling and heating in model glass-forming systems,'' Phys. Rev. E 91 (2015) 032309; xxx.lanl.gov/abs/1501.02186
  • M. Mai, K. Wang, G. Huber, M. Kirby, M. D. Shattuck, and C. S. O'Hern, ''Outcome prediction in mathematical models of immune response to infection,'' PloS ONE 10 (2015) e0135861; xxx.lanl.gov/abs/1503.08324
  • Z. Shao, Z. Liu, J. P. Singer, H. Li, Y. Liu, M. Gopinadhan, C. S. O'Hern, C. O. Osuji, and J. Schroers, ''Shear accelerated crystallization in a supercooled atomic liquid,'' Phys. Rev. E 91 (2014) 020301(R); xxx.lanl.gov/abs/1407.2078
  • A. Q. Zhou, C. S. O'Hern, and L. Regan, ''Predicting the side-chain dihedral angle distributions of non-polar, aromatic, and polar amino acids using hard-sphere models,'' Proteins: Structure, Function, and Bioinformatics 82 (2014) 2574.
  • K. Wang, V. Bhandari, C. S. O'Hern, M. D. Shattuck, and M. Kirby,''Angiopoietin-1, Angiopoietin-2, and Bicarbonate as diagnostic biomarkers in children with severe sepsis,'' PloS One 9 (2014) e108461.
  • C. F. Schreck, C. S. O'Hern, and M. D. Shattuck, ''Vibrations of jammed disk packings with Hertzian interactions,'' Granular Matter 16 (2014) 209; xxx.lanl.gov/abs/1309.0798
  • K. Zhang, W. W. Smith, M. Wang, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Connection between the packing efficiency of binary hard spheres and the glass-forming ability of bulk metallic glasses'' Phys. Rev. E 90 (2014) 032311; xxx.lanl.gov/abs/1404.0465
  • T. Shen, S. Papanikolaou, C. S. O'Hern, and M. D. Shattuck, ''The statistics of frictional families,'' Phys. Rev. Lett. 113 (2014) 128302; xxx.lanl.gov/abs/1402.0774
  • W. W. Smith, P.-Y. Ho, and C. S. O'Hern, ''Calibrated Langevin dynamics simulations of intrinsically disordered proteins,'' Phys. Rev. E 90 (2014) 042709; xxx.lanl.gov/abs/1401.0960
  • D. Caballero, J. Määttä, A. Q. Zhou, M. Sammalkorpi, C. S. O'Hern, and L. Regan, ''Intrinsic α-helix and β-sheet propensities: A computational case study of Alanine,'' Protein Science 23 (2014) 970.
  • T. Bertrand, C. F. Schreck, C. S. O'Hern, and M. D. Shattuck, ''Hypo-coordinated solids in particulate media,'' Phys. Rev. E 89 (2014) 062203; xxx.lanl.gov/abs/1307.0440
  • N. Geerts, C. F. Schreck, P. A. Beales, C. S. O'Hern, and T. K. Vanderlick, ''Using DNA-driven assembled phospholipid nanodiscs as a scaffold for gold nanoparticle patterning,'' Langmuir 29 (2013) 13089.
  • B. R. Parry, I. V. Surovtsev, M. T. Cabeen, C. S. O'Hern, E. R. Dufresne, and C. Jacobs-Wagner, ''Cellular metabolism fluidizes the glass-like cytoplasm of bacteria,'' Cell 156 (2013) 183.
  • K. Zhang, M. Wang, S. Papanikolaou, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Computational studies of the glass-forming ability of model bulk metallic glasses,'' J. Chem. Phys. 139 (2013) 124503; xxx.lanl.gov/abs/1305.0971
  • K. Wang, V. Bhandari, S. Chepustanova, G. Huber, S. O'Hara, C. S. O'Hern, M. D. Shattuck, and M. Kirby, ''Which biomarkers reveal neonatal sepsis,'' PloS One 8 (2013) e82700.
  • C. S. O'Hern and M. D. Shattuck, ''Highly evolved grains,'' Nature Materials 12 (2013) 287.
  • S. O'Hara, K. Wang, G. Huber, C. S. O'Hern, M. D. Shattuck, R. A. Slayden, A. Schenkel, and M. Kirby, ''Iterative feature removal yields highly discriminative pathways and supports biological discovery,'' BMC Genomics 14 (2013) 832.
  • C. F. Schreck, R. S. Hoy, C. S. O'Hern, and M. D. Shattuck, ''Particle-scale reversibility in athermal particulate media below jamming,'' Phys. Rev. E 88 (2013) 052205; xxx.lanl.gov/abs/1301.7492
  • Z. Shao, M. Gopinadhan, G. Kumar, S. Mukherjee, Y. Liu, C. S. O'Hern, J. Schroers, and C. Osuji, ''Size-dependent viscosity in the supercooled liquid state of a bulk metallic glass,'' App. Phys. Lett. 102 (2013) 221901.
  • A. Q. Zhou, D. Caballero, C. S. O'Hern, and L. Regan, ''New insights into the interdependence between amino acid stereochemistry and protein structure,'' Biophys. J. 105 (2013) 2403.
  • R. S. Hoy, J. Harwayne-Gidansky, and C. S. O'Hern, ''Minimal energy packings of nearly flexible polymers,'' J. Chem. Phys. 138 (2013) 054905; xxx.lanl.gov/abs/1210.3712
  • S. Papanikolaou, C. S. O'Hern, and M. D. Shattuck, ''Isostaticity at frictional jamming,'' Phys. Rev. Lett. 110 (2013) 198002; xxx.lanl.gov/abs/1207.6010

Positions

  • Chair for the American Physical Society Topical Group on Statistical and Nonlinear Physics (2010)
  • Director of Undergraduate Programs, Raymond and Beverly Sackler Institute for Biological, Physical, and Engineering Sciences (2008-present)
  • Co-founder and member of Executive Committee for Yale's Integrated Graduate Program in Physical and Engineering Biology (2008-present)
  • Director of Undergraduate Studies, Department of Mechanical Engineering & Materials Science (2011-present)

Additional Websites

The Sackler Institute

Integrated Graduate Program in Physical and Engineering Biology (IGPPEB)