Tissue Imaging Mass Spectrometry

Time: Thursday, October 19, 2017 - 10:00am - 3:00pm
Winslow Auditorium
60 College Street
New Haven, CT 06511
United States

Tissue Imaging Mass Spectrometry

Tissue imaging mass spectrometry permits high-resolution spatial localization of metabolites, proteins and drugs within tissue sections in situ, allowing assessment of metabolic changes at the cellular level. When mass spectrometry images are overlaid onto conventional histology images it is possible to determine the molecules that correlate with tissue pathology, cell type, drug distribution and toxicity. This technique is particularly applicable to cancer research where molecules can be characterized with tumor cells and their microenvironment, allowing direct therapeutic e ects to be assessed. Please join the Yale School of Public Health for this symposium, that will explore advances and challenges in tissue imaging mass spectrometry.

Vasilis Vasiliou
Professor & Chair, Dept. Environmental Health Sciences
Yale School of Public Health, Yale Cancer Center

Keynote Speaker: Richard Caprioli 
Professor of Biochemistry, Director of the Mass Spectrometry Research Center
Vanderbilt University School of Medicine, USA
Imaging Mass Spectrometry: Molecular Microscopy for Biological/ Clinical Research

Richard Goodwin
Principal Scientist, Mass Spectrometry Imaging
AstraZeneca, UK
The Role of Mass Spectrometry Imaging in Oncology Drug Discovery

Stephen Castellino
Senior GSK Fellow and Head of US Ex Vivo Imaging
GlaxoSmithKline, USA
Imaging MS: Visualizing Drug Disposition and Pharmacology in Tissue

Kirill A. Veselkov
Department of Surgery and Cancer
Imperial College London, UK
Translational Data analytics for large-scale MSI data

Kevin L. Schey
Professor of Biochemistry and Ophthalmology & Visual Sciences, Deputy Director of Research, Imaging Mass Spectrometry Center
Vanderbilt University School of Medicine, USA
Imaging Mass Spectrometry of Ocular Tissues: Molecular Signatures of Aging and Disease

Per E. Andrén
Professor of Mass Spectrometry Imaging, Director of National Resource for Mass Spectrometry Imaging, Dept. of Pharmaceutical Biosciences
Uppsala University, Uppsala, Sweden
Mapping the Brain Neurotransmitter Network with Mass Spectrometry Imaging Directly in Tissue Sections

Michael Angelo
Assistant Professor, Department of Pathology
Stanford University School of Medicine, USA
High Dimensional IHC in Clinical Tissue Biopsies Using Multiplexed Ion Beam Imaging

Sheerin K. Shahidi-Latham
Head of Metabolomics & Imaging MS, Drug Metabolism & Pharmacokinetics Department
Genentech, Member of the Roche Group, USA
High-Resolution Imaging MALDI Mass Spectrometry to Support Drug Discovery and Development

Roundtable chaired by Mark Duncan and Caroline Johnson

Lunch, Wine and cheese included. Admission is free.

Register: http://publichealth.yale.edu/ehs/research/conferences/spectrometry/