Corey S. O'Hern

Professor of Mechanical Engineering & Materials Science, Physics, Applied Physics & Graduate Program in Computational Biology & Bioinformatics
Room / Office: Mason 203
Office Address:
9 Hillhouse Avenue
New Haven, CT 06511
Mailing Address:
P.O. Box 208286
New Haven, CT 06520
Phone: (203) 432-4258
Email: corey.ohern@yale.edu
Degrees:

Ph.D., University of Pennsylvania

Interests:

Statistical mechanics of nonequilibrium systems; glass and jamming transitions in soft matter; computational biology; protein structure, interactions, and design.

Selected Awards & Honors:

  • Ackerman Teaching Award (2018)
  • Elected Fellow of the American Physical Society (2017)
  • Cyber-Enabled Discovery and Innovation Award from the National Science Foundation (2008)
  • Faculty Early Career Development Award from the National Science Foundation (2005)

Selected Publications:

  • C. Oi, J. T. Treado, Z. A. Levine, C. S. Lim, K. M. Knecht, Y. Xiong, C. S. O'Hern, and L. Regan, ''A threonine zipper that mediates protein-protein interactions: Structure and prediction,'' Protein Science 27 (2018) 1969.
  • S. Chen, T. Bertrand, W. Jin, M. D. Shattuck, and C. S. O'Hern, ''Stress anisotropy in shear-jammed packings of frictionless disks,'' Phy. Rev. E 98 (2018) 042906.
  • A. H. Clark, M. D. Shattuck, N. T. Ouellette, and C. S. O'Hern, ''Critical scaling near the yielding transition in granular media,'' Phys. Rev. E 97 (2018) 062901.
  • J. C. Gaines, S. Acebes, A. Virrueta, M. Butler, L. Regan, and C. S. O'Hern, ''Comparing side chain packing in soluble proteins, protein-protein interfaces, and transmembrane proteins,'' Proteins: Structure, Function, and Bioinformatics 86 (2018) 581.
  • K. VanderWerf, W. Jin, M. D. Shattuck, and C. S. O'Hern, ''Hypostatic jammed packings of frictionless nonspherical particles,'' Phys. Rev. E 97 (2018) 012909.
  • J. C. Gaines, A. Virrueta, D. A. Buch, S. J. Fleishman, C. S. O'Hern, and L. Regan, ''Collective repacking reveals that the structures of protein cores are uniquely specified by steric repulsive interactions,'' Protein Eng. Des. Sel. 30 (2017) 387.
  • J. C. Gaines, A. H. Clark, L. Regan, and C. S. O'Hern, ''Packing of protein cores,'' J. Phys.: Condens. Matter 29 (2017) 293001.
  • K. Zhang, C.-C. Kuo, N. See, C. S. O'Hern, and M. Dennin, "Stable small bubble clusters in two-dimensional foams,'' Soft Matter 13 (2017) 4370.
  • Q. Wu, T. Bertrand, M. D. Shattuck, and C. S. O'Hern, ''The response of jammed packings to thermal fluctuations,'' Phys. Rev. E 96 (2017) 062902.
  • A. H. Clark, N. T. Ouellette, M. D. Shattuck, and C. S. O'Hern, ''The role of grain dynamics in determining the onset of sediment transport,'' Phys. Rev. Fluids 2 (2017) 034305.
  • M. Fan, K. Zhang, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Particle rearrangement and softening contributions to the nonlinear mechanical response of glasses,'' Phys. Rev. E 96 (2017) 032602.
  • M. Fan, M. Wang, K. Zhang, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''The effects of cooling rate on particle rearrangement statistics: Rapidly cooled glasses are more ductile and less reversible,'' Phys. Rev. E 95 (2017) 022611.
  • T. Bertrand, R. P. Behringer, B. Chakraborty, C. S. O'Hern, and M. D. Shattuck, ''Protocol dependence of the jamming transition,'' Phys. Rev. E 93 (2016) 012901.
  • D. Caballero, A. Virrueta, C. S. O'Hern, and L. Regan, ''Steric interactions alone determine side chain conformations in protein cores,'' Protein Eng. Des. Sel. 29 (2016) 367.
  • J. C. Gaines, W. W. Smith, L. Regan, and C. S. O'Hern, ''Random close packing in protein cores,'' Phys. Rev. E 93 (2016) 032415.
  • A. Virrueta, C. S. O'Hern, and L. Regan, ''Understanding the physical basis for the side chain conformational preferences of Met,'' Proteins: Structure, Function, and Bioinformatics 84 (2016) 900.
  • M. Wang, K. Zhang, Z. Li, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Asymmetric crystallization during cooling and heating in model glass-forming systems,'' Phys. Rev. E 91 (2015) 032309.
  • K. Zhang, M. Fan, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Beyond packing of hard spheres: The effects of core softness, non-additivity, intermediate-range repulsion, and many-body interactions on the glass-forming ability of bulk metallic glasses,'' J. Chem. Phys. 143 (2015) 184502.
  • K. Zhang, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''The glass-forming ability of model metal-metalloid alloys,'' J. Chem. Phys. 142 (2015) 104504.
  • K. Zhang, B. Dice, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''On the origin of multi-component bulk metallic glasses: Atomic size mismatches and de-mixing,'' J. Chem. Phys. 143 (2015) 054501.
  • A. H. Clark, M. D. Shattuck, N. T. Ouellette and C. S. O'Hern, ''Onset and cessation of motion in hydrodynamically sheared granular beds,'' Phys. Rev. E 92 (2015) 042202.
  • M. Mai, K. Wang, G. Huber, M. Kirby, M. D. Shattuck, and C. S. O'Hern, ''Outcome prediction in mathematical models of immune response to infection,'' PLoS ONE 10 (2015) e0135861.
  • D. Caballero, W. W. Smith, C. S. O'Hern, and L. Regan, ''Equilibrium transitions between side chain conformations in leucine and isoleucine,'' Proteins: Structure, Function, and Bioinformatics 83 (2015) 1488.
  • T. Bertrand, C. F. Schreck, C. S. O'Hern, and M. D. Shattuck, ''Hypo-coordinated solids in particulate media,'' Phys. Rev. E 89 (2014) 062203.
  • K. Zhang, W. W. Smith, M. Wang, Y. Liu, J. Schroers, M. D. Shattuck, and C. S. O'Hern, ''Connection between the packing efficiency of binary hard spheres and the glass-forming ability of bulk metallic glasses,'' Phys. Rev. E 90 (2014) 032311.
  • W. W. Smith, P.-Y. Ho, and C. S. O'Hern, ''Calibrated Langevin dynamics simulations of intrinsically disordered proteins,'' Phys. Rev. E 90 (2014) 042709.
  • A. Q. Zhou, C. S. O'Hern, and L. Regan, ''Predicting the side-chain dihedral angle distributions of non-polar, aromatic, and polar amino acids using hard-sphere models,'' Proteins: Structure, Function, and Bioinformatics 82 (2014) 2574.
  • D. Caballero, J. Määttä, A. Q. Zhou, M. Sammalkorpi, C. S. O'Hern, and L. Regan, ''The intrinsic α-helical and β-sheet preferences: A computational case study of Alanine,'' Protein Science 23 (2014) 970.
  • T. Shen, S. Papanikolaou, C. S. O'Hern, and M. D. Shattuck, ''The statistics of frictional families,'' Phys. Rev. Lett. 113 (2014) 128302.
  • C. F. Schreck, C. S. O'Hern, and M. D. Shattuck, ''Vibrations of jammed disk packings with Hertzian interactions,'' Granular Matter 16 (2014) 209.

Positions

  • Chair for the American Physical Society Topical Group on Statistical and Nonlinear Physics (2010)
  • Director of Undergraduate Programs, Raymond and Beverly Sackler Institute for Biological, Physical, and Engineering Sciences (2008-present)
  • Co-founder and member of Executive Committee for Yale's Integrated Graduate Program in Physical and Engineering Biology (2008-present)
  • Director of Undergraduate Studies, Department of Mechanical Engineering & Materials Science (2011-present)

Additional Websites

The Sackler Institute

Integrated Graduate Program in Physical and Engineering Biology (IGPPEB)