Biomedical Engineering Undergraduate Courses

Below are the courses frequently offered in Biomedical Engineering. For the most up-to-date course offerings and lecturer information, visit Yale University’s Online Course Information site. Click here for the listing of courses in Engineering & Applied Science (general courses for undergraduate students in any branch of Engineering).

BENG 205, Discovery and Design in Biomedical Research 
The course will introduce a clinical dilemma, that is, a medical or surgical need, and help students to learn how to work together effectively to identify a solution that stems from a multi-disciplinary approach. Toward this end, we will focus on precision regenerative medicine as an illustrative area of study for it involves aspects of bioengineering, materials science, immunobiology, mechanobiology, computational modeling, and experimental design. We will also advance to hands-on fabrication and materials testing (i.e., data collection and analysis). To focus our study, we will consider in detail the design of a drug-eluting, tissue engineered vascular conduit for surgical treatment of a congenital heart defect that is diagnosed and treated in early childhood. This topic also offers the opportunity to understand contributions from diverse areas of clinical collaboration, including surgery and cardiology. Because the solution is open-ended it will enable a true classroom directed research experience. Although focused on a single clinical need, all of the methods learned will be generally applicable to a host of clinical needs.. 

BENG 350aG/MCDB 310aG, Physiological Systems
Regulation and control in biological systems, emphasizing human physiology and principles of feedback. Biomechanical properties of tissues emphasizing the structural basis of physiological control. Conversion of chemical energy into work in light of metabolic control and temperature regulation. Prerequisites: CHEM 113b or 115b, or PHYS 180a and 181b; MCDB 120a.

BENG 351a/CENG 351a, Biomedical Engineering I: Quantitative Physiology
Together with the companion course BENG 352b, a yearlong presentation of the fundamentals of biomedical engineering. Demonstration of the use of engineering analysis and synthesis in problems in the life sciences and medicine; focus on modeling of molecular physiological processes and design of artificial organs. Lectures are coordinated with BENG 350a to illustrate how engineering analysis can be used to understand physiological processes. Additional topics include pharmacokinetics, heat and mass transfer in physiological systems, hemodialysis, drug delivery, and tissue engineering. Concurrently with BENG 350a. Prerequisites: MCDB 120a, CHEM 112a, 114a, or 118a; PHYS 180a, 181b; MATH 115a or b; ENAS 194a or b.

BENG 352b/EENG 352b, Biomedical Engineering II
In conjunction with BENG 351a, a comprehensive introduction to the field of biomedical engineering. Topics include biosignals, medical imaging, mathematical modeling of biosystems, and biomechanics. Prerequisites: PHYS 180a and 181b, MATH 115a or b, and ENAS 194a or b.

BENG 355La and 356Lb, Biomedical Engineering Laboratory
Introduction to laboratory techniques and tools used for physiological measurement in biomedical engineering. Topics include bioelectric measurement, bioimaging technologies, signal processing, and dialysis. Enrollment limited.

BENG 405bG/EVST 415b, Biotechnology and the Developing World
Study of technological advances that have global health applications. Ways in which biotechnology has enhanced quality of life in the developing world. The challenges of implementing relevant technologies in resource-limited environments, including technical, practical, social, and ethical aspects. Prerequisites: MCDB 120a.

BENG 410a, Physical and Chemical Basis of Bioimaging and Biosensing
Basic principles and technologies for sensing the chemical, electrical, and structural properties of living tissues and of biological macromolecules. Topics include magnetic resonance spectroscopy, microelectrodes, fluorescent probes, chip-based biosensors, X-ray and electron tomography, and MRI. Prerequisites: BENG 351a and 352b or permission of instructor.

BENG 411bG, Biomedical Microtechnology and Nanotechnology
Principles and applications of micro- and nanotechnologies for biomedicine. Approaches to fabricating micro- and nanostructures. Fluid mechanics, electrokinetics, and molecular transport in microfluidic systems. Integrated biosensors and microTAS for laboratory medicine and point-of-care uses. High-content technologies, including DNA, protein microarrays, and cell-based assays for differential diagnosis and disease stratification. Emerging nanobiotechnology for systems medicine. Prerequisites: CHEM 112a, 114a, or 118a, and ENAS 194a or b.

BENG 421bG, Fundamentals of Medical Imaging
The physics of image formation, with special emphasis on techniques with medical applications. Emphasis on concepts common to different types of imaging, along with understanding how information is limited by physical phenomena. Topics include mathematical concepts of image analysis; formation of images by ionizing radiation; ultrasound; NMR and other energy forms; and methods of evaluating image quality. Prerequisites: ENAS 194a or b, and PHYS 180a, 181b, or 200a, 201b, or permission of instructor.

BENG 434a, Biomaterials
Introduction to the major classes of biomedical materials: ceramics, metals, and polymers. Their structure, properties, and fabrication connected to biological applications, from implants to tissue-engineered devices and drug delivery systems. Prerequisite: CHEM 113b or 115b; organic chemistry recommended.

BENG 435bG, Biomaterial-Tissue Interactions
Study of the interactions between tissues and biomaterials, with an emphasis on the importance of molecular- and cellular-level events in dictating the performance and longevity of clinically relevant devices. Attention to specific areas such as biomaterials for tissue engineering and the importance of stem/progenitor cells, as well as biomaterial-mediated gene and drug delivery. Prerequisites: CHEM 112a, 114a, or 118a, and MCDB 120a, or equivalents.

BENG 445aG/EENG 445aG, Biomedical Image Processing and Analysis
A study of the basic computational principles related to processing and analysis of biomedical images (e.g., magnetic resonance, computed X-ray tomography, fluorescence microscopy). Basic concepts and techniques related to discrete image representation, multidimensional frequency transforms, image enhancement, motion analysis, image segmentation, and image registration. Prerequisite: EENG 310b or permission of instructors. Recommended preparation: familiarity with probability theory.

BENG 449bG, Biomedical Data Analysis
Study of biological and medical data analysis associated with applications of biomedical engineering. Provides basics of probability and statistics, as well as analytical approaches for determination of quantitative biological parameters from experimental data. Includes substantial programming in MATLAB. Prerequisite: MATH 120a or b or ENAS 151a or b. After or concurrently with ENAS 194a or b.

BENG 457bG/MENG 457b, Biomechanics
An introduction to the application of mechanical engineering principles to biological materials and systems. Topics include ligament, tendon, bone, muscle; joints, gait analysis; exercise physiology. The basic concepts are directed toward an understanding of the science of orthopedic surgery and sports medicine. Prerequisites: MENG 280a and 383a or permission of instructor.

BENG 464b, Tissue Engineering
Introduction to the major aspects of tissue engineering, including materials selection, scaffold fabrication, cell sources, cell seeding, bioreactor design, drug delivery, and tissue characterization. Class sessions include lectures and hands-on laboratory work. Prerequisite: CHEM 112a, 114a, or 118a. Recommended preparation: organic chemistry.

BENG 471a and 472b, Special Projects
Faculty-supervised individual or small-group projects with emphasis on research (laboratory or theory), engineering design, or tutorial study. Students are expected to consult the director of undergraduate studies and appropriate faculty members about ideas and suggestions for suitable topics. This course is usually taken during the spring term of the senior year but with permission of the director of undergraduate studies can be taken any time during a student’s career, and may be taken more than once. Permission of both the instructor and the director of undergraduate studies is required.

BENG 475bG/CPSC 475bG, Computational Vision and Biological Perception
For description see under Computer Science in Yale College Programs of Study.

BENG 480aG, Seminar in Biomedical Engineering
Oral presentations and written reports by students analyzing papers from scientific journals on topics of interest in biomedical engineering, including discussions and advanced seminars from faculty on selected subjects.

BENG 485bG, Fundamentals of Neuroimaging
The neuroenergetic and neurochemical basis of several dominant neuroimaging methods, including fMRI. Topics include technical aspects of different methods, interpretation of results, and controversies or challenges regarding the application of fMRI and related methods in medicine.